Disseminated histoplasmosis causing splenic rupture in a patient receiving infliximab

Infection with the soil fungus Histoplasma capsula- tum accounts for the most prevalent endemic mycosis in the United States but it rarely results in serious and fatal disease (1). The usual manifestation of histoplasmosis is in the form of pulmonary disease, but in immunocom- promised individuals it may present as a disseminated infection (2). Hepatomegaly and splenomegaly with variable degrees of severity are known clinical manifes- tations in disseminated disease, but these are usually uncomplicated. We present the first reported case of disseminated histoplasmosis complicated by splenic rupture.